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Indeed, radon exposure is very important to consider the case of light smokers, whose tobacco-related cancer risk might be low, but if combined with radon can become as high as a heavy smoker, as the differing types of DNA damage elicited by tobacco carcinogens (nitrosamines, benzene, aldehydes and polyaromatic hydrocarbons) combine with the effects of alpha particle radiation-induced ionization to increase genomic instability

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Ward, Kate (December 11, 2009)